Est. by clinical research  ·  Evidence-Based
Greet Health

A curated menu of empirically supported treatments for depression

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We source only from peer-reviewed research, randomized controlled trials, and clinical meta-analyses. Each dish has been refined over decades. We recommend consulting your physician or therapist before selecting your tasting menu.

First Course
Psychotherapies
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Cognitive Behavioral Therapy Gold Standard
CBT · Structured · 12–20 sessions
Our signature preparation. A bold, structured flavor profile — challenging automatic negative thoughts and reframing cognitive distortions. Presented with behavioral activation on the side. Consistently the most replicated treatment in the literature.
thought restructuring behavioral activation skill-building relapse prevention
★★★★★
Effect size
Behavioral Activation
BA · Accessible · 8–16 sessions
A lighter, more approachable preparation distilled from CBT. Pure and elemental — re-engaging with pleasurable and meaningful activities to interrupt the cycle of withdrawal. Deceptively simple, remarkably effective, and easy on the palate.
activity scheduling values-alignment anti-avoidance
★★★★☆
Effect size
Interpersonal Therapy
IPT · Relational · 12–16 sessions
A richly relational flavor. Focuses on grief, role transitions, interpersonal disputes, and social isolation — the social roots of mood. Smooth finish with lasting improvement in relationship quality.
grief processing role transitions communication
★★★★☆
Effect size
Acceptance & Commitment Therapy
ACT · Mindful · Ongoing
A contemplative, Eastern-inflected preparation. Rather than fighting difficult thoughts, this dish teaches psychological flexibility — holding pain lightly while moving toward what matters. Subtle, complex, and deeply satisfying for those with a palate for paradox.
psychological flexibility defusion values clarification mindfulness
★★★★☆
Effect size
Second Course
Pharmacological Preparations
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SSRIs Most Prescribed
Fluoxetine · Sertraline · Escitalopram · & more
The house standard. Selective serotonin reuptake inhibitors offer a reliable, well-tolerated baseline. Notes of mood stabilization with a characteristically mild onset — allow 4–6 weeks for full flavor development. Best enjoyed under close physician guidance.
serotonin modulation well-tolerated long-term option
★★★★☆
Effect size
SNRIs
Venlafaxine · Duloxetine · Dual-action
A more complex, dual-action preparation — serotonin and norepinephrine both present in the profile. Slightly bolder than SSRIs, with particular depth for those with comorbid anxiety or pain. A sophisticated choice for those who've tried the lighter dishes.
dual reuptake inhibition anxiety pairing chronic pain
★★★★☆
Effect size
Bupropion
NDRI · Energizing · Single serving daily
Distinctly energizing, with dopaminergic and noradrenergic notes that few competitors can match. Notably absent: sexual side effects. A favored selection for those with fatigue-predominant depression or who prefer to avoid weight gain. Also carries a smoking cessation finish.
dopamine & norepinephrine activating weight-neutral
★★★★☆
Effect size
Mirtazapine Atypical
NaSSA · Sedating · Once nightly
A rich, full-bodied preparation unlike anything else on the menu. Mirtazapine works through an entirely different mechanism — blocking alpha-2 autoreceptors to increase both norepinephrine and serotonin release, while also antagonising H1 receptors for a pronounced sedative effect. Particularly well-suited to depression with insomnia, poor appetite, or significant weight loss. No sexual side effects. Weight gain is a common trade-off.
norepinephrine & serotonin sedating appetite stimulation no sexual side effects
★★★★☆
Effect size
Atypical Antipsychotics Adjunct
Quetiapine · Aripiprazole · Brexpiprazole · Add-on therapy
Not a standalone preparation — this is an augmentation strategy for those who have had a partial response to an antidepressant but haven't reached remission. Low-dose atypical antipsychotics are added to the existing regimen to boost effect. Quetiapine also carries sedative properties useful for sleep disturbance. Aripiprazole and brexpiprazole tend to be more activating and weight-neutral. Metabolic monitoring is recommended with extended use.
augmentation partial responders treatment-resistant dopamine modulation
★★★★☆
Effect size
Third Course
Somatic & Neurostimulation
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Exercise Underrated
Aerobic · 3–5 sessions/week · 30–45 min
The most underordered item on our menu. A robust, full-bodied preparation — aerobic exercise produces BDNF, endorphins, and serotonin in a single preparation. Comparable to antidepressants in mild-to-moderate depression, with no prescription required. Running, cycling, swimming all accepted.
BDNF release endorphins anti-inflammatory self-efficacy
★★★★☆
Effect size
rTMS — Repetitive Transcranial Magnetic Stimulation
Non-invasive · 4–6 week course · No anesthesia
A refined, high-tech preparation for treatment-resistant palates. Magnetic pulses gently stimulate the left dorsolateral prefrontal cortex, rekindling neural circuits dimmed by depression. No systemic side effects. Increasingly available and FDA-cleared. Pairs excellently with therapy.
neuromodulation treatment-resistant non-pharmacological
★★★★☆
Effect size
Electroconvulsive Therapy
ECT · Reserved for Severe Cases · Highly Effective
Our most powerful preparation, reserved for the most persistent cases — treatment-resistant, severe, or psychotic depression. Far more refined than its historical reputation suggests. Administered under anesthesia with modern protocols. Unmatched response rates when other treatments have been exhausted.
severe depression rapid onset highest response rate
★★★★★
Effect size
Side Selections
Lifestyle & Adjunctive Preparations
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Sleep Hygiene Optimization
Behavioral · Nightly · Cumulative effect
An essential side that elevates every other preparation on the menu. Consistent sleep timing, darkness, and wind-down rituals restore the circadian rhythm often disrupted by depression. No meal is complete without it.
circadian rhythm sleep architecture restorative
★★★☆☆
Effect size
Mindfulness-Based Cognitive Therapy
MBCT · 8 weeks · Group or individual
A CBT–meditation fusion, developed specifically for recurrent depression. Exceptionally effective for preventing relapse — recommended for those with three or more prior episodes. Meditative, slow-building, and deeply sustaining over time.
relapse prevention mindfulness recurrent depression
★★★★☆
Effect size
Light Therapy
Phototherapy · 10,000 lux · 20–30 min daily
Bright, crisp, and invigorating — particularly suited to seasonal depression (SAD). Morning exposure to 10,000-lux lamps recalibrates the circadian clock and suppresses melatonin. A clean, pleasant preparation with rapid onset and minimal side effects.
seasonal depression circadian reset rapid onset
★★★★☆
Effect size
Chef's Recommendation: The Grand Combination

Research consistently shows that psychotherapy paired with pharmacotherapy outperforms either alone for moderate-to-severe depression. We recommend beginning with CBT and an SSRI, accompanied by daily exercise and disciplined sleep hygiene, for the most complete and enduring tasting experience.

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Please consult a licensed psychiatrist, psychologist, or physician before beginning any course.
This menu is informational only. Greet Health assumes no clinical liability.
For crisis support, contact 988 (Suicide & Crisis Lifeline) or your local emergency services.